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Protein

Mineralocorticoid receptor

Gene

NR3C2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei6SteroidBy similarity1
Binding sitei134SteroidBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mineralocorticoid receptor
Short name:
MR
Alternative name(s):
Nuclear receptor subfamily 3 group C member 2
Gene namesi
Name:NR3C2
Synonyms:MLR
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000053688‹1 – ›147Mineralocorticoid receptorAdd BLAST›147

Proteomic databases

PaxDbiQ8QHI2
PRIDEiQ8QHI2

Expressioni

Gene expression databases

BgeeiENSGALG00000010035

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016283

Structurei

3D structure databases

ProteinModelPortaliQ8QHI2
SMRiQ8QHI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – ›147NR LBDPROSITE-ProRule annotationAdd BLAST›147

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
InParanoidiQ8QHI2
OrthoDBiEOG091G0166

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit

Sequencei

Sequence statusi: Fragment.

Q8QHI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FALSWRSYKH TNSQFLYFAP DLIFDEERMR QSAMFELCQG MHQISLQFVR
60 70 80 90 100
LQLSFEEYTI MKVLLLLSTV PKDGLKSQAA FEEMRANYIK ELKKMVTKCP
110 120 130 140
SNSGQSWQRF YQLTKLLDSM HDLVSDLLEF CFYTFRESQA LKVEFPA
Length:147
Mass (Da):17,424
Last modified:June 1, 2002 - v1
Checksum:i152172EE332FF9AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1471

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF468211 mRNA Translation: AAL77075.1
UniGeneiGga.77

Similar proteinsi

Entry informationi

Entry nameiMCR_CHICK
AccessioniPrimary (citable) accession number: Q8QHI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: June 1, 2002
Last modified: June 20, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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