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Protein

Tyrosine-protein phosphatase non-receptor type 18

Gene

Ptpn18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in growth and differentiation of hematopoietic cells.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei197SubstrateBy similarity1
Active sitei229Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei276SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-MMU-8863795 Downregulation of ERBB2 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 18 (EC:3.1.3.48)
Alternative name(s):
Fetal liver phosphatase 1
Short name:
FLP-1
PTP-K1
Gene namesi
Name:Ptpn18
Synonyms:Flp1, Ptpk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:108410 Ptpn18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947741 – 453Tyrosine-protein phosphatase non-receptor type 18Add BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei381PhosphotyrosineCombined sources1
Modified residuei419PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ61152
MaxQBiQ61152
PaxDbiQ61152
PeptideAtlasiQ61152
PRIDEiQ61152

PTM databases

iPTMnetiQ61152
PhosphoSitePlusiQ61152

Miscellaneous databases

PMAP-CutDBiQ61152

Expressioni

Tissue specificityi

Highest expression in bone marrow. Also expressed in kidney, lung, ovary, spleen, thymus and lymph node.3 Publications

Developmental stagei

Expressed in the embryo from day 15.5.

Gene expression databases

BgeeiENSMUSG00000026126
ExpressionAtlasiQ61152 baseline and differential
GenevisibleiQ61152 MM

Interactioni

Subunit structurei

Interacts with PSTPIP1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ61152, 2 interactors
MINTiQ61152
STRINGi10090.ENSMUSP00000027302

Structurei

3D structure databases

ProteinModelPortaliQ61152
SMRiQ61152
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 291Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST266

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni229 – 235Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00900000140785
HOGENOMiHOG000115776
HOVERGENiHBG053419
InParanoidiQ61152
KOiK18024
OMAiNCAPLYD
OrthoDBiEOG091G0B5O
PhylomeDBiQ61152
TreeFamiTF351977

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q61152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRHTDLVRS FLEQLEARDY REGAILAREF SDIKARSVAW KSEGVCSTKA
60 70 80 90 100
GSRLGNTNKN RYKDVVAYDE TRVILSLLQE EGHGDYINAN FIRGIDGSQA
110 120 130 140 150
YIATQGPLPH TLLDFWRLVW EFGVKVILMA CQETENGRRK CERYWAREQE
160 170 180 190 200
PLKAGPFCIT LTKETTLNAD ITLRTLQVTF QKEFRSVHQL QYMSWPDHGV
210 220 230 240 250
PSSSDHILTM VEEARCLQGL GPGPLCVHCS AGCGRTGVLC AVDYVRQLLL
260 270 280 290 300
TQTIPPNFSL FQVVLEMRKQ RPAAVQTEEQ YRFLYHTVAQ LFSRTLQDTS
310 320 330 340 350
PHYQNLKENC APICKEAFSL RTSSALPATS RPPGGVLRSI SVPAPPTLPM
360 370 380 390 400
ADTYAVVQKR GASAGTGPGP RAPTSTDTPI YSQVAPRAQR PVAHTEDAQG
410 420 430 440 450
TTALRRVPAD QNSSGPDAYE EVTDGAQTGG LGFNLRIGRP KGPRDPPAEW

TRV
Length:453
Mass (Da):50,202
Last modified:November 1, 1996 - v1
Checksum:i88AD7E73CE8136B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11F → L in AAC52991 (PubMed:8977243).Curated1
Sequence conflicti57T → M in AAH08512 (PubMed:15489334).Curated1
Sequence conflicti95I → T in AAH08512 (PubMed:15489334).Curated1
Sequence conflicti184F → S in AAH08512 (PubMed:15489334).Curated1
Sequence conflicti362 – 368ASAGTGP → LRRHRA in AAC52991 (PubMed:8977243).Curated7
Sequence conflicti365G → V in AAH08512 (PubMed:15489334).Curated1
Sequence conflicti374T → N in AAH08512 (PubMed:15489334).Curated1
Sequence conflicti401T → I in AAH08512 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49853 mRNA Translation: AAB18623.1
U35124 mRNA Translation: AAB82736.1
U52523 mRNA Translation: AAC52991.1
AK144353 mRNA Translation: BAE25845.1
BC008512 mRNA Translation: AAH08512.1
CCDSiCCDS14867.1
RefSeqiNP_035336.2, NM_011206.2
UniGeneiMm.361

Genome annotation databases

EnsembliENSMUST00000027302; ENSMUSP00000027302; ENSMUSG00000026126
GeneIDi19253
KEGGimmu:19253
UCSCiuc007aos.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPTN18_MOUSE
AccessioniPrimary (citable) accession number: Q61152
Secondary accession number(s): Q4JFH4, Q62404, Q922E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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