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Protein

Calpain-13

Gene

Capn13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable non-lysosomal thiol-protease.By similarity

Caution

It is unlikely that this protein binds calcium as none of the 2 EF-hand domains seem to contain a canonical calcium-binding site.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91By similarity1
Active sitei247By similarity1
Active sitei271By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiR-MMU-1474228 Degradation of the extracellular matrix

Protein family/group databases

MEROPSiC02.020

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-13 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 13
Short name:
CANP 13
Gene namesi
Name:Capn13
Synonyms:Gm943
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2685789 Capn13

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595831 – 665Calpain-13Add BLAST665

Proteomic databases

MaxQBiQ3UW68
PaxDbiQ3UW68
PeptideAtlasiQ3UW68
PRIDEiQ3UW68

PTM databases

PhosphoSitePlusiQ3UW68

Expressioni

Gene expression databases

BgeeiENSMUSG00000043705
CleanExiMM_CAPN13
GenevisibleiQ3UW68 MM

Interactioni

Protein-protein interaction databases

BioGridi237788, 1 interactor
STRINGi10090.ENSMUSP00000092832

Structurei

3D structure databases

ProteinModelPortaliQ3UW68
SMRiQ3UW68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 329Calpain catalyticPROSITE-ProRule annotationAdd BLAST300
Domaini534 – 569EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini632 – 665EF-hand 2PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037 Eukaryota
KOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00760000118971
HOGENOMiHOG000232035
HOVERGENiHBG012645
InParanoidiQ3UW68
KOiK08581
OMAiYLTEMEW
OrthoDBiEOG091G03KK
PhylomeDBiQ3UW68
TreeFamiTF314748

Family and domain databases

CDDicd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR036213 Calpain_III_sf
IPR029544 CANP13/Calpain-C
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF333 PTHR10183:SF333, 1 hit
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00230 CysPc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF49758 SSF49758, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS50222 EF_HAND_2, 2 hits
PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UW68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHDAETSVV KFKNQDFRTL RDHCLSRGQL FIDDTFPAAA SSIGEKLLRG
60 70 80 90 100
KHLSKLEWKR PTSKDLPFYP PHFILEGASR FDIHQGIAGD CWFLAALGSL
110 120 130 140 150
TQNPQCLQKI LMDQSYSHQY AGIFQFRFWQ CGQWVEVVID DQLPVIGDNF
160 170 180 190 200
LFVHPRGGNK EFWPCLMEKA YAKLLGSYSQ LHYGYLPDAL VDLTGGVVTI
210 220 230 240 250
INLHSSPFDL LTTVKTAIQA GSMVACATEN GLTEEAKVME NGLVSQHAYT
260 270 280 290 300
VTGAEKIQYQ GRWEDIIRLW NPWGKTEWKG RWKDGSKEWR ETHDPRKSQL
310 320 330 340 350
YENKEDGEFW MSCQDFQENF SCLFICNQIP ITMDHGVTPN ESWRQMRFTN
360 370 380 390 400
QVISRNRAGG HGRDMQYVFS VQEHTAGNNV VVAFTIMPQS LNTEEERFPL
410 420 430 440 450
QFQVFKVPQF QNVQGRLPPA FFSPFRSAAQ GTKYVSKCNF TKSFHLNPGT
460 470 480 490 500
YVVVTTANGK EVEFLLRIFL KMPDKHRDPS SNFNLRALKE SLPENGSRNS
510 520 530 540 550
ISYTYMDQGL DIDATQLQSL LNQEFLTGPP GDTFSLDQCQ SIMALMDLKV
560 570 580 590 600
NGRLDQEEFA RLRSRLIHCQ HIFQSIQRRP GVLLSSDLWK VIENTDFLVG
610 620 630 640 650
IFISSELLSL MALRYSDSSG RVSFPTLVCF LIRLETMAKA FRNLSKDGKG
660
IYLTETEWMN LVMYS
Length:665
Mass (Da):76,049
Last modified:October 11, 2005 - v1
Checksum:i7C1AA17FD2D14D6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136569 mRNA Translation: BAE23051.1
BC147510 mRNA Translation: AAI47511.1
BC147512 mRNA Translation: AAI47513.1
CCDSiCCDS37690.1
RefSeqiNP_001028616.1, NM_001033444.2
UniGeneiMm.81496

Genome annotation databases

EnsembliENSMUST00000095208; ENSMUSP00000092832; ENSMUSG00000043705
GeneIDi381122
KEGGimmu:381122
UCSCiuc008dnj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCAN13_MOUSE
AccessioniPrimary (citable) accession number: Q3UW68
Secondary accession number(s): B2RW21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2005
Last modified: June 20, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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