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Protein

Chymotrypsin-like protease CTRL-1

Gene

CTRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay systemBy similarity1
Active sitei121Charge relay systemBy similarity1
Active sitei214Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: GO_Central

GO - Biological processi

  • protein catabolic process Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.256

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like protease CTRL-1 (EC:3.4.21.-)
Gene namesi
Name:CTRL
Synonyms:CTRL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000141086.17
HGNCiHGNC:2524 CTRL
MIMi118888 gene
neXtProtiNX_P40313

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi1506
PharmGKBiPA27025

Chemistry databases

ChEMBLiCHEMBL4873

Polymorphism and mutation databases

BioMutaiCTRL
DMDMi729224

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000002766019 – 33Activation peptideSequence analysisAdd BLAST15
ChainiPRO_000002766134 – 264Chymotrypsin-like protease CTRL-1Add BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi19 ↔ 141PROSITE-ProRule annotation
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi155 ↔ 220PROSITE-ProRule annotation
Disulfide bondi187 ↔ 201PROSITE-ProRule annotation
Disulfide bondi210 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiP40313
PaxDbiP40313
PeptideAtlasiP40313
PRIDEiP40313
ProteomicsDBi55361

PTM databases

iPTMnetiP40313
PhosphoSitePlusiP40313

Expressioni

Gene expression databases

BgeeiENSG00000141086
CleanExiHS_CTRL
ExpressionAtlasiP40313 baseline and differential
GenevisibleiP40313 HS

Organism-specific databases

HPAiHPA034504
HPA034505

Interactioni

Protein-protein interaction databases

BioGridi107886, 4 interactors
IntActiP40313, 2 interactors
MINTiP40313
STRINGi9606.ENSP00000458537

Chemistry databases

BindingDBiP40313

Structurei

3D structure databases

ProteinModelPortaliP40313
SMRiP40313
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 262Peptidase S1PROSITE-ProRule annotationAdd BLAST229

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOVERGENiHBG013304
InParanoidiP40313
KOiK09632
OMAiQCRQYWG
OrthoDBiEOG091G0AH5
PhylomeDBiP40313

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P40313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLSLTLSL VLLGSSWGCG IPAIKPALSF SQRIVNGENA VLGSWPWQVS
60 70 80 90 100
LQDSSGFHFC GGSLISQSWV VTAAHCNVSP GRHFVVLGEY DRSSNAEPLQ
110 120 130 140 150
VLSVSRAITH PSWNSTTMNN DVTLLKLASP AQYTTRISPV CLASSNEALT
160 170 180 190 200
EGLTCVTTGW GRLSGVGNVT PAHLQQVALP LVTVNQCRQY WGSSITDSMI
210 220 230 240 250
CAGGAGASSC QGDSGGPLVC QKGNTWVLIG IVSWGTKNCN VRAPAVYTRV
260
SKFSTWINQV IAYN
Length:264
Mass (Da):28,002
Last modified:February 1, 1995 - v1
Checksum:i3F629F02FA6DDFB4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051834150T → I. Corresponds to variant dbSNP:rs11552953Ensembl.1
Natural variantiVAR_021939173H → R. Corresponds to variant dbSNP:rs1134760Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71874 Genomic DNA Translation: CAA50710.1
X71877 mRNA Translation: CAA50711.1
BC063475 mRNA Translation: AAH63475.1
CCDSiCCDS10852.1
PIRiI38136
RefSeqiNP_001898.1, NM_001907.2
UniGeneiHs.654546

Genome annotation databases

EnsembliENST00000574481; ENSP00000458537; ENSG00000141086
GeneIDi1506
KEGGihsa:1506
UCSCiuc002euw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCTRL_HUMAN
AccessioniPrimary (citable) accession number: P40313
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 20, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

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