Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Brachyury protein

Gene

T

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi51 – 219T-boxPROSITE-ProRule annotationAdd BLAST169

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • BMP signaling pathway Source: MGI
  • bone morphogenesis Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cardiac muscle cell differentiation Source: UniProtKB
  • cellular response to retinoic acid Source: Ensembl
  • determination of heart left/right asymmetry Source: MGI
  • embryonic skeletal system development Source: MGI
  • heart morphogenesis Source: MGI
  • mesoderm development Source: MGI
  • mesoderm migration involved in gastrulation Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: BHF-UCL
  • neural plate morphogenesis Source: MGI
  • neural tube closure Source: MGI
  • notochord development Source: MGI
  • notochord formation Source: MGI
  • penetration of zona pellucida Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: BHF-UCL
  • post-anal tail morphogenesis Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • reproductive process Source: MGI
  • signal transduction involved in regulation of gene expression Source: MGI
  • SMAD protein signal transduction Source: MGI
  • somitogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • vasculogenesis Source: MGI

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Brachyury protein
Alternative name(s):
Protein T
Gene namesi
Name:T
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:98472 T

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Embryo lacking the T gene fail to form the notochord, the entire posterior region and the allantois, and die at about 10 days of gestation.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844151 – 436Brachyury proteinAdd BLAST436

Proteomic databases

PaxDbiP20293
PRIDEiP20293

PTM databases

PhosphoSitePlusiP20293

Expressioni

Developmental stagei

During gastrula and neurula stages in involuting mesoderm and in the notochord.

Gene expression databases

BgeeiENSMUSG00000062327
CleanExiMM_T
ExpressionAtlasiP20293 baseline and differential
GenevisibleiP20293 MM

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
Mixl1Q9WUI07EBI-13637160,EBI-13637214

GO - Molecular functioni

  • RNA polymerase II activating transcription factor binding Source: BHF-UCL
  • RNA polymerase II transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

DIPiDIP-61216N
IntActiP20293, 3 interactors
STRINGi10090.ENSMUSP00000074236

Structurei

3D structure databases

ProteinModelPortaliP20293
SMRiP20293
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00900000140847
HOGENOMiHOG000063663
HOVERGENiHBG004599
InParanoidiP20293
KOiK10172
OMAiAPSCVYI
OrthoDBiEOG091G05OC
PhylomeDBiP20293
TreeFamiTF106341

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR002070 TF_Brachyury
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00938 BRACHYURY
PR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequencei

Sequence statusi: Complete.

P20293-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPGTESAG KSLQYRVDHL LSAVESELQA GSEKGDPTER ELRVGLEESE
60 70 80 90 100
LWLRFKELTN EMIVTKNGRR MFPVLKVNVS GLDPNAMYSF LLDFVTADNH
110 120 130 140 150
RWKYVNGEWV PGGKPEPQAP SCVYIHPDSP NFGAHWMKAP VSFSKVKLTN
160 170 180 190 200
KLNGGGQIML NSLHKYEPRI HIVRVGGPQR MITSHCFPET QFIAVTAYQN
210 220 230 240 250
EEITALKIKY NPFAKAFLDA KERNDHKDVM EEPGDCQQPG YSQWGWLVPG
260 270 280 290 300
AGTLCPPASS HPQFGGSLSL PSTHGCERYP ALRNHRSSPY PSPYAHRNSS
310 320 330 340 350
PTYADNSSAC LSMLQSHDNW SSLGVPGHTS MLPVSHNASP PTGSSQYPSL
360 370 380 390 400
WSVSNGTITP GSQTAGVSNG LGAQFFRGSP AHYTPLTHTV SAATSSSSGS
410 420 430
PMYEGAATVT DISDSQYDTA QSLLIASWTP VSPPSM
Length:436
Mass (Da):47,440
Last modified:February 1, 1991 - v1
Checksum:i1A0BDF9BA7FC2484
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51683 mRNA Translation: CAA35985.1
CCDSiCCDS28383.1
PIRiS08156
RefSeqiNP_033335.1, NM_009309.2
XP_011244504.1, XM_011246202.1
UniGeneiMm.913

Genome annotation databases

EnsembliENSMUST00000074667; ENSMUSP00000074236; ENSMUSG00000062327
GeneIDi20997
KEGGimmu:20997
UCSCiuc008ajq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBRAC_MOUSE
AccessioniPrimary (citable) accession number: P20293
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: March 28, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health