Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP/ATP translocase 3

Gene

SLC25A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.1 Publication

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80ADPBy similarity1
Binding sitei92ADPBy similarity1
Binding sitei235ADPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Host-virus interaction, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-168277 Influenza Virus Induced Apoptosis
R-HSA-180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
R-HSA-422356 Regulation of insulin secretion

Protein family/group databases

TCDBi2.A.29.1.10 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 3
Alternative name(s):
ADP,ATP carrier protein 3
ADP,ATP carrier protein, isoform T2
Short name:
ANT 2
Adenine nucleotide translocator 3
Short name:
ANT 3
Solute carrier family 25 member 6
Cleaved into the following chain:
Gene namesi
Name:SLC25A6
Synonyms:ANT3
ORF Names:CDABP0051
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000169100.13
HGNCiHGNC:10992 SLC25A6
MIMi300151 gene
403000 gene
neXtProtiNX_P12236

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 37Helical; Name=1By similarityAdd BLAST30
Transmembranei75 – 99Helical; Name=2By similarityAdd BLAST25
Transmembranei110 – 130Helical; Name=3By similarityAdd BLAST21
Transmembranei179 – 199Helical; Name=4By similarityAdd BLAST21
Transmembranei211 – 231Helical; Name=5By similarityAdd BLAST21
Transmembranei274 – 291Helical; Name=6By similarityAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi293
OpenTargetsiENSG00000169100
PharmGKBiPA35868

Chemistry databases

DrugBankiDB00720 Clodronate

Polymorphism and mutation databases

BioMutaiSLC25A6
DMDMi113463

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004257811 – 298ADP/ATP translocase 3Add BLAST298
Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00000905842 – 298ADP/ATP translocase 3, N-terminally processedAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in ADP/ATP translocase 3, N-terminally processedCombined sources1 Publication1
Modified residuei52N6,N6,N6-trimethyllysineCombined sources1
Modified residuei105N6-acetyllysineCombined sources1
Modified residuei268N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiP12236
PaxDbiP12236
PeptideAtlasiP12236
PRIDEiP12236
ProteomicsDBi52837
TopDownProteomicsiP12236

PTM databases

iPTMnetiP12236
PhosphoSitePlusiP12236
SwissPalmiP12236

Expressioni

Gene expression databases

BgeeiENSG00000169100
CleanExiHS_SLC25A6
ExpressionAtlasiP12236 baseline and differential
GenevisibleiP12236 HS

Organism-specific databases

HPAiHPA046835
HPA071684

Interactioni

Subunit structurei

Found in a complex with ARL2, ARL2BP and SLC25A6 (By similarity). Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr.By similarity2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi106790, 137 interactors
IntActiP12236, 66 interactors
MINTiP12236
STRINGi9606.ENSP00000370808

Structurei

3D structure databases

ProteinModelPortaliP12236
SMRiP12236
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 240Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 240Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOVERGENiHBG108348
InParanoidiP12236
KOiK05863
OMAiNGKRQFK
OrthoDBiEOG091G0ULB
PhylomeDBiP12236
TreeFamiTF300743

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQAISFAK DFLAGGIAAA ISKTAVAPIE RVKLLLQVQH ASKQIAADKQ
60 70 80 90 100
YKGIVDCIVR IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDKHTQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKSGT
160 170 180 190 200
EREFRGLGDC LVKITKSDGI RGLYQGFSVS VQGIIIYRAA YFGVYDTAKG
210 220 230 240 250
MLPDPKNTHI VVSWMIAQTV TAVAGVVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YTGTVDCWRK IFRDEGGKAF FKGAWSNVLR GMGGAFVLVL YDELKKVI
Length:298
Mass (Da):32,866
Last modified:January 23, 2007 - v4
Checksum:i18534E9F0E49672F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105 – 108KHTQ → RHA in AAA36750 (PubMed:2829183).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054819242S → F1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007135 mRNA Translation: AAG01998.1
BC007295 mRNA Translation: AAH07295.1
BC007850 mRNA Translation: AAH07850.1
BC008737 mRNA Translation: AAH08737.1
BC008935 mRNA Translation: AAH08935.1
BC014775 mRNA Translation: AAH14775.1
BC031912 mRNA Translation: AAH31912.1
J03592 mRNA Translation: AAA36750.1
CCDSiCCDS14114.1
PIRiS03894
RefSeqiNP_001627.2, NM_001636.3
UniGeneiHs.350927
Hs.680626

Genome annotation databases

EnsembliENST00000381401; ENSP00000370808; ENSG00000169100
GeneIDi293
KEGGihsa:293

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiADT3_HUMAN
AccessioniPrimary (citable) accession number: P12236
Secondary accession number(s): Q96C49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 209 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health