Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP/ATP translocase 2

Gene

SLC25A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80ADPBy similarity1
Binding sitei92ADPBy similarity1
Binding sitei235ADPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processChromosome partition, Host-virus interaction, Transport

Enzyme and pathway databases

ReactomeiR-HSA-180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
R-HSA-422356 Regulation of insulin secretion

Protein family/group databases

TCDBi2.A.29.1.1 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 2
Alternative name(s):
ADP,ATP carrier protein 2
ADP,ATP carrier protein, fibroblast isoform
Adenine nucleotide translocator 2
Short name:
ANT 2
Solute carrier family 25 member 5
Cleaved into the following chain:
Gene namesi
Name:SLC25A5
Synonyms:ANT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000005022.5
HGNCiHGNC:10991 SLC25A5
MIMi300150 gene
neXtProtiNX_P05141

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 37Helical; Name=1By similarityAdd BLAST30
Transmembranei75 – 99Helical; Name=2By similarityAdd BLAST25
Transmembranei110 – 130Helical; Name=3By similarityAdd BLAST21
Transmembranei179 – 199Helical; Name=4By similarityAdd BLAST21
Transmembranei211 – 231Helical; Name=5By similarityAdd BLAST21
Transmembranei274 – 291Helical; Name=6By similarityAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi292
OpenTargetsiENSG00000005022
PharmGKBiPA35867

Chemistry databases

DrugBankiDB00720 Clodronate

Polymorphism and mutation databases

BioMutaiSLC25A5
DMDMi317373597

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004232201 – 298ADP/ATP translocase 2Add BLAST298
Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00000905792 – 298ADP/ATP translocase 2, N-terminally processedAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in ADP/ATP translocase 2, N-terminally processedCombined sources2 Publications1
Modified residuei7PhosphoserineBy similarity1
Modified residuei23N6-malonyllysine1 Publication1
Modified residuei43N6-succinyllysineBy similarity1
Modified residuei52N6,N6,N6-trimethyllysine; alternateCombined sources1
Modified residuei52N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei52N6-methyllysine; alternate1 Publication1
Modified residuei92N6-malonyllysine1 Publication1
Modified residuei96N6-malonyllysine1 Publication1
Modified residuei105N6-acetyllysine; alternateCombined sources1
Modified residuei105N6-succinyllysine; alternateBy similarity1
Modified residuei147N6-acetyllysine; alternateBy similarity1
Modified residuei147N6-malonyllysine; alternate1 Publication1
Modified residuei147N6-methyllysine; alternateCombined sources1
Modified residuei147N6-succinyllysine; alternateBy similarity1
Modified residuei163N6-acetyllysineCombined sources1
Modified residuei166N6-acetyllysineBy similarity1
Modified residuei268N6-acetyllysine; alternateBy similarity1
Modified residuei268N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP05141
MaxQBiP05141
PaxDbiP05141
PeptideAtlasiP05141
PRIDEiP05141
ProteomicsDBi51804
TopDownProteomicsiP05141

PTM databases

iPTMnetiP05141
PhosphoSitePlusiP05141
SwissPalmiP05141

Expressioni

Gene expression databases

BgeeiENSG00000005022
CleanExiHS_SLC25A5
GenevisibleiP05141 HS

Organism-specific databases

HPAiHPA046835
HPA071684

Interactioni

Subunit structurei

Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with HIV-1 Vpr.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi106789, 153 interactors
CORUMiP05141
DIPiDIP-33873N
IntActiP05141, 87 interactors
MINTiP05141
STRINGi9606.ENSP00000360671

Structurei

3D structure databases

ProteinModelPortaliP05141
SMRiP05141
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 240Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 240Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOVERGENiHBG108348
InParanoidiP05141
KOiK05863
OMAiFRGIHHF
OrthoDBiEOG091G0ULB
PhylomeDBiP05141
TreeFamiTF300743

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDAAVSFAK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQITADKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDKRTQFW LYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKAGA
160 170 180 190 200
EREFRGLGDC LVKIYKSDGI KGLYQGFNVS VQGIIIYRAA YFGIYDTAKG
210 220 230 240 250
MLPDPKNTHI VISWMIAQTV TAVAGLTSYP FDTVRRRMMM QSGRKGTDIM
260 270 280 290
YTGTLDCWRK IARDEGGKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYT
Length:298
Mass (Da):32,852
Last modified:January 11, 2011 - v7
Checksum:iDC53D083E7217AFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6V → L in AAA35579 (PubMed:3031073).Curated1
Sequence conflicti43K → M in BAG37698 (PubMed:14702039).Curated1
Sequence conflicti66G → E in AAA35579 (PubMed:3031073).Curated1
Sequence conflicti162V → G in AAA36749 (PubMed:2829183).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030039111L → R4 PublicationsCorresponds to variant dbSNP:rs371749Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57424 Genomic DNA Translation: AAA51737.1
J02683 mRNA Translation: AAA35579.1
L78810 Genomic DNA Translation: AAB39266.1
AK315292 mRNA Translation: BAG37698.1
AC004000 Genomic DNA Translation: AAB96347.1
BC056160 mRNA Translation: AAH56160.1
J03591 mRNA Translation: AAA36749.1
CCDSiCCDS14578.1
PIRiA29132
RefSeqiNP_001143.2, NM_001152.4
UniGeneiHs.632282

Genome annotation databases

EnsembliENST00000317881; ENSP00000360671; ENSG00000005022
GeneIDi292
KEGGihsa:292
UCSCiuc004erh.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiADT2_HUMAN
AccessioniPrimary (citable) accession number: P05141
Secondary accession number(s): B2RCV1, O43350
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 207 of the entry and version 7 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health