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Protein

Long-wave-sensitive opsin 1

Gene

OPN1LW

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

Absorptioni

Abs(max)=560 nm

GO - Molecular functioni

  • G-protein coupled photoreceptor activity Source: GO_Central
  • photoreceptor activity Source: CACAO

GO - Biological processi

  • phototransduction Source: UniProtKB-KW
  • positive regulation of cytokinesis Source: UniProtKB
  • protein-chromophore linkage Source: UniProtKB-KW
  • retinoid metabolic process Source: Reactome
  • signal transduction Source: ProtInc
  • visual perception Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological processSensory transduction, Vision
LigandChromophore

Enzyme and pathway databases

ReactomeiR-HSA-2187335 The retinoid cycle in cones (daylight vision)
R-HSA-2453864 Retinoid cycle disease events
R-HSA-418594 G alpha (i) signalling events
R-HSA-419771 Opsins

Protein family/group databases

TCDBi9.A.14.1.1 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Long-wave-sensitive opsin 1
Alternative name(s):
Red cone photoreceptor pigment
Red-sensitive opsin
Short name:
ROP
Gene namesi
Name:OPN1LW
Synonyms:RCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102076.9
HGNCiHGNC:9936 OPN1LW
MIMi300822 gene
neXtProtiNX_P04000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularAdd BLAST52
Transmembranei53 – 77Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini78 – 89CytoplasmicAdd BLAST12
Transmembranei90 – 115Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini116 – 129ExtracellularAdd BLAST14
Transmembranei130 – 149Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini150 – 168CytoplasmicAdd BLAST19
Transmembranei169 – 192Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini193 – 218ExtracellularAdd BLAST26
Transmembranei219 – 246Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini247 – 268CytoplasmicAdd BLAST22
Transmembranei269 – 292Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini293 – 300Extracellular8
Transmembranei301 – 325Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini326 – 364CytoplasmicAdd BLAST39

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Colorblindness, partial, protan series (CBP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA color vision defect characterized by a dichromasy in which red and green are confused, with loss of luminance and shift of brightness and hue curves toward the short wave end of the spectrum. Dichromasy is due to the use of only two types of photoreceptors, blue plus red in deuteranopia and blue plus green in protanopia.
See also OMIM:303900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064054338G → E in CBP. 1 Publication1
Blue cone monochromacy (BCM)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare X-linked congenital stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity, pendular nystagmus, and photophobia. Patients often have myopia.
See also OMIM:303700
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009298203C → R in BCM. 2 Publications1
Natural variantiVAR_009299307P → L in BCM. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi5956
GeneReviewsiOPN1LW
MalaCardsiOPN1LW
MIMi303700 phenotype
303900 phenotype
Orphaneti16 Blue cone monochromatism
1872 Cone rod dystrophy
319691 Partial color blindness, protan type
PharmGKBiPA31936

Chemistry databases

ChEMBLiCHEMBL1949482

Polymorphism and mutation databases

DMDMi129219

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978021 – 364Long-wave-sensitive opsin 1Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi126 ↔ 203PROSITE-ProRule annotation
Modified residuei312N6-(retinylidene)lysine1

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP04000
PeptideAtlasiP04000
PRIDEiP04000
ProteomicsDBi51630

Expressioni

Tissue specificityi

The three color pigments are found in the cone photoreceptor cells.

Gene expression databases

BgeeiENSG00000102076
CleanExiHS_OPN1LW
ExpressionAtlasiP04000 baseline and differential
GenevisibleiP04000 HS

Interactioni

Protein-protein interaction databases

IntActiP04000, 2 interactors
STRINGi9606.ENSP00000358967

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KPXmodel-A1-364[»]
ProteinModelPortaliP04000
SMRiP04000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000253932
HOVERGENiHBG107442
InParanoidiP04000
OrthoDBiEOG091G0BDA
PhylomeDBiP04000
TreeFamiTF324998

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR000378 Opsin_red/grn
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
PR00575 OPSINREDGRN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequencei

Sequence statusi: Complete.

P04000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQQWSLQRL AGRHPQDSYE DSTQSSIFTY TNSNSTRGPF EGPNYHIAPR
60 70 80 90 100
WVYHLTSVWM IFVVTASVFT NGLVLAATMK FKKLRHPLNW ILVNLAVADL
110 120 130 140 150
AETVIASTIS IVNQVSGYFV LGHPMCVLEG YTVSLCGITG LWSLAIISWE
160 170 180 190 200
RWLVVCKPFG NVRFDAKLAI VGIAFSWIWS AVWTAPPIFG WSRYWPHGLK
210 220 230 240 250
TSCGPDVFSG SSYPGVQSYM IVLMVTCCII PLAIIMLCYL QVWLAIRAVA
260 270 280 290 300
KQQKESESTQ KAEKEVTRMV VVMIFAYCVC WGPYTFFACF AAANPGYAFH
310 320 330 340 350
PLMAALPAYF AKSATIYNPV IYVFMNRQFR NCILQLFGKK VDDGSELSSA
360
SKTEVSSVSS VSPA
Length:364
Mass (Da):40,572
Last modified:October 23, 1986 - v1
Checksum:iD9DACDC17BF20DB3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012010111I → V. Corresponds to variant dbSNP:rs1065421Ensembl.1
Natural variantiVAR_012011116S → Y. Corresponds to variant dbSNP:rs1065422Ensembl.1
Natural variantiVAR_012012153L → M. Corresponds to variant dbSNP:rs713Ensembl.1
Natural variantiVAR_004842180S → A in 38% of the population. 1 PublicationCorresponds to variant dbSNP:rs949431Ensembl.1
Natural variantiVAR_009298203C → R in BCM. 2 Publications1
Natural variantiVAR_012014230I → T. Corresponds to variant dbSNP:rs148583295Ensembl.1
Natural variantiVAR_050612274I → V. Corresponds to variant dbSNP:rs2315122Ensembl.1
Natural variantiVAR_012015298A → P. Corresponds to variant dbSNP:rs1065440Ensembl.1
Natural variantiVAR_009299307P → L in BCM. 1 Publication1
Natural variantiVAR_064054338G → E in CBP. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13305
, M13300, M13301, M13302, M13303, M13304 Genomic DNA Translation: AAB59524.1
Z68193 Genomic DNA Translation: CAA92342.1
CCDSiCCDS14742.1
PIRiA03157 OOHUR
UniGeneiHs.247787
Hs.592247

Genome annotation databases

EnsembliENST00000369951; ENSP00000358967; ENSG00000102076
UCSCiuc033fax.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOPSR_HUMAN
AccessioniPrimary (citable) accession number: P04000
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: June 20, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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