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Protein

Synapsin-3

Gene

Syn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed.

Miscellaneous

Regulated by calcium.

GO - Molecular functioni

  • ATP binding Source: RGD

GO - Biological processi

  • neurotransmitter secretion Source: RGD

Keywordsi

LigandATP-binding, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin-3
Alternative name(s):
Synapsin III
Gene namesi
Name:Syn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3799 Syn3

Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830261 – 579Synapsin-3Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9Phosphoserine; by PKA and CaMK1By similarity1
Modified residuei454PhosphoserineBy similarity1
Modified residuei461PhosphoserineCombined sources1
Modified residuei469PhosphoserineCombined sources1
Modified residuei474PhosphoserineCombined sources1
Modified residuei480PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO70441
PRIDEiO70441

PTM databases

iPTMnetiO70441
PhosphoSitePlusiO70441

Expressioni

Tissue specificityi

Expressed primarily in brain.

Interactioni

Subunit structurei

Interacts with CAPON.1 Publication

Protein-protein interaction databases

DIPiDIP-358N
MINTiO70441
STRINGi10116.ENSRNOP00000036740

Structurei

3D structure databases

ProteinModelPortaliO70441
SMRiO70441
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28AAdd BLAST28
Regioni28 – 90B; linkerAdd BLAST63
Regioni91 – 398C; actin-binding and synaptic-vesicle bindingAdd BLAST308
Regioni399 – 530J; Pro-rich linkerAdd BLAST132
Regioni531 – 579EAdd BLAST49

Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesi

Belongs to the synapsin family.Curated

Phylogenomic databases

eggNOGiKOG3895 Eukaryota
ENOG410XQH5 LUCA
HOGENOMiHOG000231323
HOVERGENiHBG016354
InParanoidiO70441
KOiK19941
PhylomeDBiO70441
TreeFamiTF319919

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR028712 SYN3
IPR001359 Synapsin
IPR020898 Synapsin_ATP-bd_dom
IPR019735 Synapsin_CS
IPR019736 Synapsin_P_site
IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERiPTHR10841 PTHR10841, 1 hit
PTHR10841:SF6 PTHR10841:SF6, 1 hit
PfamiView protein in Pfam
PF02078 Synapsin, 1 hit
PF02750 Synapsin_C, 1 hit
PF10581 Synapsin_N, 1 hit
PRINTSiPR01368 SYNAPSIN
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS00415 SYNAPSIN_1, 1 hit
PS00416 SYNAPSIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

O70441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLRRRLSD SSFVANLPNG YMPDLQRPES SSSSPASPAT ERRHPQPLAA
60 70 80 90 100
SFSSPGSSLF SSFSSAMKQT PQAPTGLMEP PTPVTPVVQR PRILLVIDDA
110 120 130 140 150
HTDWSKYFHG KKVNGDIEIR VEQAEFSELN LAAYVTGGCM VDMQVVRNGT
160 170 180 190 200
KIVRSFKPDF ILVRQHAYSM ALAEDYRSLV IGLQYGGLPA VNSLYSVYNF
210 220 230 240 250
CSKPWVFSQL IKIFHSLGPE KFPLVEQTFF PNHKPMLTAP NFPVVIKLGH
260 270 280 290 300
AHAGMGKIKV ENQHDYQDIT SVVAMAKTYA TTEAFIDSKY DIRIQKIGSN
310 320 330 340 350
YKAYMRTSIS GNWKANTGSA MLEQVAMTER YRLWVDSCSE MFGGLDICAV
360 370 380 390 400
KAVHSKNGRD YIIEVMDSSM PLIGEHVEED KQLMADLVVS KMSQLLVPGA
410 420 430 440 450
SVPSPLRPWG PQTKSAKSPG QGQLGPLLGQ PQPRPPPQGG PRQAQSPQPP
460 470 480 490 500
RSRSPSQQRL SPQGQQPVSP QSGSPQQQRS PGSPQLSRAS GGSSPNQASK
510 520 530 540 550
PTASLSSHTR PPVQGRSTSQ QGEEPQKTAS PHPHLNKSQS LTNSLSTSDT
560 570
SHRGTPSEDE AKAETIRNLR KSFASLFSD
Length:579
Mass (Da):63,349
Last modified:August 1, 1998 - v1
Checksum:iEA69F25ED14A4722
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056704 mRNA Translation: AAC24521.1
RefSeqiNP_058805.1, NM_017109.1
UniGeneiRn.162920

Genome annotation databases

GeneIDi29130
KEGGirno:29130
UCSCiRGD:3799 rat

Similar proteinsi

Entry informationi

Entry nameiSYN3_RAT
AccessioniPrimary (citable) accession number: O70441
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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